Fig. 2.

Pharmacodynamic signal of NeuroSTAT in the Copenhagen Head Injury Ciclosporin Phase Ib/IIa clinical trial. Temporal profile of brain injury biomarker neurofilament light (NF-L) in cerebrospinal fluid (CSF). A Individual levels of NF-L in CSF samples drawn at predose, during the continuous NeuroSTAT infusion, and after treatment had ended. Dashed vertical lines indicate the start and stop of infusion. CSF, cerebrospinal fluid. B Slopes of NF-L change during NeuroSTAT infusion and during follow-up after infusion stop. Data are presented as mean and SEM. *p<0.05. Adapted from [28] with permission from the publisher