Table 1.
Characteristics of the GWAS summary data.
| Comorbidity | Data source | Sample size | N cases | N controls | PMID |
|---|---|---|---|---|---|
| Respiratory tract/pulmonary comorbidities | |||||
| Obstructive sleep apnea | FinnGen-R8 | 341,071 | 33,423 | 307,648 | |
| Chronic obstructive pulmonary disease | FinnGen-R8 | 299,999 | 16,410 | 283,589 | |
| Chronic sinusitis | FinnGen-R8 | 273,192 | 14,639 | 258,553 | |
| Allergic comorbidities | |||||
| Atopic dermatitis | FinnGen-R8 | 318,873 | 11,964 | 306,909 | |
| Allergic conjunctivitis | FinnGen-R8 | 342,499 | 18,321 | 324,178 | |
| Allergic rhinitis | FinnGen-R8 | 340,880 | 9,707 | 331,173 | |
| Allergic urticaria | FinnGen-R8 | 333,382 | 2,112 | 331,270 | |
| Cardiovascular comorbidities | |||||
| Hypertension | FinnGen-R8 | 342,439 | 98,683 | 243,756 | |
| Hypertensive heart disease | FinnGen-R8 | 251,171 | 7,415 | 243,756 | |
| Heart failure | FinnGen-R8 | 341,561 | 23,622 | 317,939 | |
| Coronary heart disease | FinnGen-R8 | 342,499 | 39,036 | 303,463 | |
| Metabolic comorbidities/trait | |||||
| Type 2 diabetes | FinnGen-R8 | 332,321 | 49,114 | 283,207 | |
| Hyperthyroidism | FinnGen-R8 | 340,964 | 7,209 | 333,755 | |
| Autoimmune-related hypothyroidism | FinnGen-R8 | 287,247 | 36,321 | 250,926 | |
| Obesity | FinnGen-R8 | 342,400 | 18,330 | 324,070 | |
| Body mass index | Locke et al. (20) GIANT Consortium | 322,154 | 25673413 | ||
| Gastrointestinal comorbidities | |||||
| Gastroesophageal reflux disease | FinnGen-R8 | 315,123 | 22,867 | 292,256 | |
| Peptic ulcer | FinnGen-R8 | 300,496 | 8,240 | 292,256 | |
| Irritable bowel syndrome | FinnGen-R8 | 284,799 | 8,116 | 276,683 | |
| Ulcerative colitis | Liu et al. (21) IIBDGC | 27,432 | 6,968 | 20,464 | 26192919 |
| Crohn’s disease | Liu et al. (21) IIBDGC | 20,883 | 5,956 | 14,927 | 26192919 |
| Psychiatric and neurological comorbidities | |||||
| Depression | FinnGen-R8 | 338,111 | 38,225 | 299,886 | |
| Anxiety | FinnGen-R8 | 329,077 | 21,519 | 307,558 | |
| Epilepsy | FinnGen-R8 | 275,016 | 10,354 | 264,662 | |
| Insomnia | FinnGen-R8 | 340,820 | 3,514 | 337,306 | |
| Musculoskeletal comorbidities | |||||
| Osteoporosis | FinnGen-R8 | 332,020 | 6,303 | 325,717 | |
GIANT, Genetic Investigation of Anthropometric Traits (GIANT) Consortium; IIBDGC, International Inflammatory Bowel Disease Genetics Consortium.