Table 2.
Summary of mechanism of traditional Chinese medicine targeting inflammatory pathways in the Prevention and Treatment of GPL.
| Signnaling Pathway | Interventions | Experimental Model | Mechanism | PMID |
|---|---|---|---|---|
| MAPK | Curcumin | cisplatin (DDP)-induced mice | Suppress JNK1/2, ASK1, P38, JUN Enhance ERK1/2 and C-Myc |
36178099 |
| Rhein | H. pylori-induced mice | Regulate TNF-α,COX-2,IL-6,IL-1β and Nrf2 | 36789982 | |
| Panax Notoginseng Saponins | MMNG-induced rats | Regulate TLR2, TLR4/MAPK/NF-κB/iNOS | / | |
| JAK/STAT3 | Calycosin | H. pylori-induced rats | Regulate the integrin β1/NF-κB/DARPP-32 Inhibit STAT3 |
32606591 |
| Danggui Shaoyao Powder | H. pylori-induced rats | Up-regulate SOCS3 Down-regulate TLR4, p-JAK2, p-STAT3, NF-κB, MyD88, NLRP3, Bax, Bad |
36046903 | |
| PI3K/AKT/mTOR | Berberine | MMNG-induced rats | Down-regulate TGF-β1, PI3K, p-Akt/Akt, p-mTOR/mTOR P70S6K Promote PTEN, LC3-II Beclin-1 |
33841162 |
| Epigallocatechin | MNNG and sodium salicylate-induced rats | Upregulate caspase-3, PTEN Reduce PI3K, Akt, mTOR |
33628319 | |
| Rg3 | Atp4a-induced mice | Regulate PI3K, AKT, mTOR, HIF-1β, LDHA, HK-II | 32076440 | |
| Xiaojianzhong decoction | MNNG compound(MNNG, hot ranitidine-salt solution and 20% ethanol) induced rats | Decrease PI3K/AKT/mTOR Inhibit the p53/AMPK, ULK1 Ser-317, Ser-555 |
37009319 | |
| Hippo | Radix curcumae extract | MMNG-induced rats | Down-regulate VEGF, COX-2, PCNA | 20210736 |
| Red Ginseng extract | H. pylori-induced Mongolian gerbils | Suppress KC, IL-1β iNOS | 24558304 | |
| Huazhuo Jiedu formula | MMNG-induced rats | Down-regulate TAZ Up-regulate LATS2 and MST1 |
/ | |
| Hedgehog | Modified Gualou Xiebai Banxia Decoction, | MMNG-induced rats | Suppress JAK2/STAT3 Promote Hedgehog |
/ |
| Weiweikang | Sodium-salicylate-induced rats | Suppress Smo、Shh and SuFu | / | |
| Spleen-fortifying, fire-clearing and collateral-unblocking medicinals | MNNG compound(MNNG, hot ranitidine-salt solution and 20% ethanol) induced rats | Improve IL-1β, GAS Reactivate Hedgehog signal pathway |
/ | |
| Wnt/β-catenin | Dendrobium officinale polysaccharide | MMNG-induced rats | Downregulate Wnt2β, Gsk3β, PCNA, CyclinD1, β-catenin | 31340453 |
| Liquiritigenin | MMNG-induced rats | Decrease Wnt1, β-catenin, cyclin D1 Increased GSK-3β |
34194556 |