TABLE 1.
Demographic, clinical and epidemiological data.
| Desensitized group N = 14 |
Control group N = 42 |
p-value | |
|---|---|---|---|
| Demographic | |||
| Female | 9 (64.3) | 22 (52.4) | 0.32 |
| Male | 5 (35.7) | 20 (47.6) | 0.32 |
| Age, m (SD) | 72.8 (±7.5) | 73.5 (±13.8) | 0.49 |
| Comorbidities | |||
| CHARLSON, m (SD) | 7.4 (±3.3) | 5 (±2.3) | 0.01 |
| Diabetes mellitus | 5 (35.7) | 11 (26.2) | 0.36 |
| Respiratory disease | 8 (57.1) | 11 (26.2) | 0.04 |
| Heart disease | 6 (42.9) | 12 (28.6) | 0.25 |
| Chronic kidney disease | 5 (35.7) | 5 (11.9) | 0.05 |
| Liver disease | 3 (21.4) | 3 (7.1) | 0.16 |
| Solid malignancy | 5 (35.7) | 10 (23.8) | 0.29 |
| Haematological neoplasm | 0 (0) | 1 (2.4) | 0.75 |
| Neurological disease | 5 (35.7) | 4 (9.5) | 0.03 |
| Critical care unit | 5 (35.7) | 13 (31) | 0.49 |
| Infection source | 0.78 | ||
| -Pulmonary | 2 (14.3) | 11 (26.2) | |
| -Intraabdominal | 3 (21.4) | 8 (19) | |
| -SST | 2 (14.3) | 7 (16.7) | |
| -Pancreaticobiliary | 1 (7.1) | 6 (14.3) | |
| -Endovascular | 2 (14.3) | 4 (9.5) | |
| -Endocarditis | 3 (21.4) | 3 (7.1) | |
| -Central nervous system | 1 (7.1) | 3 (7.1) | |
| Infection data | |||
| Hospital-acquired | 5 (35.7) | 20 (47.6) | 0.32 |
| Community-acquired | 9 (64.3) | 22 (52.4) | 0.32 |
| Post-surgical infection | 5 (35.7) | 16 (38.1) | 0.57 |
| Bloodstream infection | 10 (71.4) | 22 (52.4) | 0.17 |
| QuickSOFA, m (SD) | 0.9 (±0.9) | 0.9 (±0.9) | 0.84 |
| Polymicrobial | 6 (42.9) | 11 (26.2) | 0.19 |
| MDR pathogens a | 8 (57.1) | 12 (28.6) | 0.05 |
Data are presented as n (%), unless otherwise specified. SST: skin and soft tissue. quickSOFA: quick Sequential Organ Failure Assessment. MDR: multidrug-resistant.
a
At least one MDR pathogen present in cultures. Statistical significance at p < 0.05.