Inset details describe the landmark INCAP study and the proposed SHINE study, both of which provide long-term follow-up of a nutrition intervention. Data from the landmark INCAP study in Guatemala 50 years ago indicate that early-life improvements in nutrition can confer long-term benefits for cognition. Children receiving additional nutrition by age 2 years initially had only modest effects on neurodevelopmental scores; however, in long-term follow-up, those who had received the nutrition intervention had higher IQ scores, greater work capacity and earnings (among men) and greater schooling (among women)
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. The INCAP study was conducted at a time when global stunting prevalence was much higher (1969–1977): 50% of the study population had HAZ<-3.0, while currently worldwide 22% children have HAZ <-2.0. Furthermore, the impact of the intervention on linear growth was much greater than that seen in trials of complementary feeding interventions over the past 20 years (+0.62 HAZ compared to +0.11 HAZ). Thus, although the Guatemala trial suggests that complementary feeding interventions can have substantial long-term physical and neurodevelopmental benefits, it does not reflect today’s situation in which Africa has the highest stunting prevalence, severe stunting is relatively rare but moderate stunting is 20–40%, and the average impact of interventions on HAZ is only 0.1-0.2. UNICEF, United Nations Children's Fund; WHO, World Health Organization; INCAP, Institute of Nutrition of Central America and Panama; SHINE, Sanitation Hygiene Infant Nutrition Efficacy; HAZ, height-for-age Z-score; Ppln, population; Rnd, randomisation technique; Intn, Intervention; WASH, water, sanitation and hygiene.