FIGURE 1.

Metabolic reprogramming affects the abundance of key metabolites and metabolic enzymes in the nucleus. Within the tumorigenic microenvironment, aberrant metabolic activity amplifies metabolic flux, thereby accelerating the turnover rates of molecular entities and augmenting the concentration of intranuclear metabolites. Elevated levels of metabolic enzymes stand as a primary determinant in shaping the metabolic landscape of cancer cells. These enzymes translocate into the nuclear compartment, where they contribute to the augmented abundance of pivotal metabolites and enzymes. These, in turn, modulate gene expression through a diverse array of molecular modifications including methylation (denoted as Met), acetylation (Ac), O‐glycosylation (G), and lipidation (L). Nuclear metabolic enzymes are emphasized within the figure for clarity.