FIGURE 3.

The interplay between nuclear metabolic signaling and RNA methylation. Nuclear metabolic signaling components, including SAM, methionine, NADP, and NAD, impact an array of RNA methylation modifications, such as m6A, m5C, m1A, and m7G, among others. These modifications can be enzymatically installed or removed by “writers” (methyltransferases) and “erasers” (demethylases), and are discerned by their respective “readers” (e.g., YTHDF1 and 2 for m6A modification). In the cytoplasmic milieu, m6A modifications and their regulatory elements partake in mRNA translation, stability, maturation, and RNA–protein interactions, collectively contributing to the advancement of oncogenesis.