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Loss of FOXO3 improves RBC production in β-thalassemia. (A) FOXO3 ablation alters BM erythroblast frequencies. ∗P < .05 between WT and Hbbth3/+ groups and #P < .05 between Hbbth3/+ and Foxo3−/−/Hbbth3/+ groups (n ≥ 3). (B) Fold change of annexin V+ cells in live Foxo3−/−, Hbbth3/+, and Foxo3−/−/Hbbth3/+ relative to WT BM TER119+ cells in each gate. ∗P < .05, ∗∗P < .01. (C) Macroscopic examination of the spleen from WT, Hbbth3/+, and Foxo3−/−/Hbbth3/+. Results are shown as mean ± SD.
