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. 2023 Sep 9;7(22):6873–6885. doi: 10.1182/bloodadvances.2022007655

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© 2023 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

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Figure 5. — Modulation of FOXO3 and TP53 expression in p21^−/−/Hbb^th3/+ erythroid cells. (Ai) FOXO3 nuclear localization in erythroid progenitors from WT, p21^−/−, Hbb^th3/+, and p21^−/−/Hbb^th3/+ mice using confocal microscopy; analyses of at least 40 cells (quantification, right graph). Scale bar: 5 μm. (Aii) TP53 nuclear localization in erythroid progenitors from WT, p21^−/−, Hbb^th3/+, and p21^−/−/Hbb^th3/+ mice using confocal microscopy; analyses of at least 40 cells (quantification, right graph). Scale bar: 5 μm. (B) Histograms of Mitotracker Green staining of TER119⁺ cells in different gates (left) and quantification (right). (C) Mitochondrial morphology in erythroid progenitors from WT, p21^−/−, Hbb^th3/+, and p21^−/−/Hbb^th3/+ mice using confocal microscopy; analyses of at least 30 cells. Scale bar: 5 μm. Quantification of mitochondrial area (top). Results are shown as mean ± standard error of the mean; ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001; and n.s., not significant.