Table 1.
MIC99 (μg/mL) values determined in 7H9 broth supplemented with OADC of TCS analogs against M. tuberculosis mc26230, M. marinum M strain and in CaMHB at 30 °C against the rough variant of M. abscessus CIP104536T (3 independent experiments).
| Entry | |||||||
|---|---|---|---|---|---|---|---|
| M. tuberculosis | M. tuberculosis pMV261:inhAMTB | M. abscessus | M. abscessus pMV261:inhAMAB | M. abscessus pMV261:inhAMAB (G96V) | M. abscessus pMV261:inhAMAB (G96S) | M. marinum | |
| 11a | 25 | 50 | 3.125 | 3.125 | 3.125 | 3.125 | 25 |
| 11b | 25 | 25 | 0.78 | 0.78 | 0.78 | 0.78 | 25 |
| 11c | >100 | >100 | 25 | 25 | 25 | 25 | >100 |
| 11d | 12.5 | 25 | 12.5 | 12.5 | 12.5 | 12.5 | 12.5 |
| 11e | 6.25 | 12.5 | 1.56 | 1.56 | 1.56 | 1.56 | 12.5 |
| 11f | 6.25 | 6.25 | 1.56 | 1.56 | 1.56 | 1.56 | 6.25 |
| 11g | 25 | 25 | 6.25 | 6.25 | 6.25 | 6.25 | 25 |
| 11h | 12.5 | 25 | 12.5 | 12.5 | 12.5 | 12.5 | 12.5 |
| 11i | 6.25 | 6.25 | 3.125 | 3.125 | 3.125 | 3.125 | 12.5 |
| 11j | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
| 11k | 12.5 | 12.5 | 3.125 | 3.125 | 3.125 | 3.125 | 12.5 |
| TCS | 12.5 | 25 | 3.125 | 3.125 | 3.125 | 3.125 | 6.25 |
| NITD-916 | <0.195 | 1.56 | 1.56 | 3.125 | 25 | 50 | 3.125 |
| INH | 0.05 | 0.8 | ND | ND | ND | ND | 3.125 |
| RFB | ND | ND | 12.5 | 12.5 | 12.5 | 12.5 | ND |