Table 2.
In vitro cytotoxicity evaluation of 11a-k in human THP-1 macrophages, exposed for 1 day or 3 days with increasing concentrations of each compound and calculated selectivity indices (SI).
| Entry | Cytotoxicity CC50 (Day-1) | Selectivity index |
Cytotoxicity CC50 (Day-3) | Selectivity index |
||||
|---|---|---|---|---|---|---|---|---|
| M. tuberculosis | M. abscessus | M. marinum | M. tuberculosis | M. abscessus | M. marinum | |||
| 11a | 22 ± 0.12 | 0.88 | 7.04 | 0.88 | 6.26 ± 0.22 | 0.25 | 2.00 | 0.25 |
| 11b | 20.72 ± 2.6 | 0.83 | 26.56 | 0.82 | 4.27 ± 1.07 | 0.34 | 5.47 | 0.17 |
| 11c | 46.1 ± 1.3 | – | 1.84 | – | 0.91 ± 0.3 | – | 0.03 | – |
| 11d | 19.21 ± 0.3 | 1.53 | 1.53 | 1.53 | 4.04 ± 0.9 | 0.32 | 0.32 | 0.32 |
| 11e | 12.01 ± 0.25 | 1.92 | 7.70 | 0.96 | 3.38 ± 0.45 | 0.54 | 2.16 | 0.27 |
| 11f | 8.78 ± 0.37 | 1.40 | 5.62 | 1.40 | 1.74 ± 0.38 | 0.27 | 1.11 | 0.27 |
| 11g | 33.35 ± 1.71 | 1.33 | 5.33 | 1.33 | 11.31 ± 1.7 | 0.45 | 1.80 | 0.45 |
| 11h | 15.74 ± 0.8 | 1.25 | 1.26 | 1.25 | 4.32 ± 0.36 | 0.34 | 0.17 | 0.34 |
| 11i | 7.6 ± 1.3 | 1.21 | 2.43 | 0.60 | 1.56 ± 0.25 | 0.24 | 0.49 | 0.12 |
| 11j | >100 | – | – | – | 53.1 ± 7.5 | – | – | – |
| 11k | 6.49 ± 0.31 | 0.51 | 2.08 | 0.51 | 2.4 ± 0.24 | 0.19 | 0.38 | 0.19 |
| TCS | 11.321 ± 0.11 | 0.90 | 3.62 | 1.81 | 6.67 ± 0.67 | 0.53 | 2.13 | 1.06 |
| INH | >100 | – | – | – | >100 | – | – | – |