Table 1.
Demographic data and clinical information of participants
| Variables | Haemophilia A (n = 90) Number (%) |
Haemophilia B (n = 10) Number (%t) |
P value |
|---|---|---|---|
| Age at diagnosis (year) | |||
| < 1 | 56 (62.2) | 4 (50) | – |
| 1–5 | 16 (17.7) | 2 (25) | |
| 5–10 | 6 (6.6) | 1 (12.5) | |
| > 10 | 12 (11.1) | 1(12.5) | |
| Current age (Y) mean (SD) | 31.6 (14.4) | 30.5 (20.6) | 0.82 |
| Severity of disease | |||
| Mild | 16 (17.8) | 1 (10) | 0.027 |
| Moderate | 1 (1.1) | 2 (20) | |
| Severe | 73 (81.1) | 7 (70) | |
| Inhibitor | |||
| No | 88 (97.8) | 10 (100) | < 0.999 |
| Yes | 2 (2.2) | 0 (0) | |
| Annual bleeding | |||
| 1–3 | 19 (21.1) | 4 (40) | 0.306 |
| 4–6 | 21 (23.3) | 3 (30) | |
| 7–12 | 45 (50) | 2 (20) | |
| < 12 | 5 (5.6) | 1 (10) | |
| Treatment | |||
| Prophylaxis | 14(15.6) | 4(40) | 0.077 |
| On-demand | 76(84.4) | 6(60) | |
| Number of joints involved | |||
| Single joint | 6 (6.7) | 1 (10) | 0.481 |
| Multiple joints | 84 (93.3) | 9 (90) | |
| Target joint | |||
| Yes | 39 (43.3) | 0 (0) | 0.006 |
| No | 51 (56.7) | 10 (100) | |
| Radiosynovectomy by 32P chromic phosphate | |||
| Yes | 18 (20) | 2 (20) | > 0.999 |
| No | 72 (80) | 8 (80) | |
| History of surgery | |||
| Yes | 16 (17.8) | 2 (20) | > 0.999 |
| No | 74 (82.2) | 8 (80) | |
| Fracture | |||
| Yes | 6 (6.7) | 0 (0) | > 0.999 |
| No | 84 (93.3) | 10 (100) | |
| Osteoporosis | |||
| Yes | 35 (38.9) | 4 (40) | > 0.999 |
| No | 55 (61.1) | 6 (60) | |
| Hepatitis C infection | |||
| Active | |||
| Yes | 14 (15.6) | 0 (0) | 0.349 |
| No | 76 (84.4) | 10 (100) | |
| History | |||
| Yes | 26 (28.9) | 0 (0) | 0.060 |
| No | 64 (71.1) | 10 (100) | |
| Osteoarthritis | |||
| Yes | 59(65.6) | 5(50) | 0.489 |
| No | 31(34.4) | 5(50) | |