Table 2.
Comparison of factors affecting skeletal manifestations in patients with hemophilia
| Variables | Skeletal manifestations number (%) | ||||||
|---|---|---|---|---|---|---|---|
| Subgroups | Fracture | Synovitis | Osteoporosis | Target joint | Osteoarthritis | Bone disease | |
| Severity of disease | Severe | 6 (7.5) | 16 (20) | 35 (43.8) | 37 (46.3) | 53 (66.3) | 68 (85) |
| Non-severe | 0 (0) | 0 (0) | 4 (20) | 2 (10) | 11 (55) | 12 (60) | |
| P value | 0.59 | 0.03 | 0.07 | < 0.001 | 0.43 | 0.02 | |
| Type of hemophilia | A | 6 (6.7) | 14 (15.6) | 35 (38.9) | 39 (43.3) | 59 (65.6) | 74 (82.2) |
| B | 0 (0) | 2 (20) | 4 (40) | 0 (0) | 5 (50) | 6 (60) | |
| P value | > 0.99 | 0.66 | > 0.99 | < 0.001 | 0.48 | 0.11 | |
| Treatment | On-demand | 6 (7.3) | 11 (13.4) | 30 (36.6) | 35 (42.7) | 55 (67.1) | 68 (82.9) |
| prophylaxis | 0 (0) | 5 (27.8) | 9 (50) | 4 (22.2) | 9 (50) | 12 (66.7) | |
| P value | 0.588 | 0.158 | 0.301 | 0.120 | 0.186 | 0.189 | |
| History of hepatitis C infection | Yes | 4 (5.4) | 13 (17.6) | 29 (39.2) | 21 (28.4) | 45 (60.8) | 56 (75.7) |
| No | 2 (7.7) | 3 (11.5) | 10 (38.5) | 18 (69.2) | 19 (73.1) | 24 (92.3) | |
| P value | 0.649 | 0.552 | > 0.999 | < 0.001 | 0.344 | 0.089 | |
| Active hepatitis C infection | Yes | 6 (7) | 13 (15.1) | 36 (41.9) | 29 (33.7) | 55 (64) | 68 (79.1) |
| No | 0 (0) | 3 (21.4) | 3 (21.4) | 10 (71.4) | 9 (64.3) | 12 (85.7) | |
| P value | 0.591 | 0.693 | 0.237 | 0.015 | > 0.999 | 0.730 | |
| Annual bleeding rate | 1–3 | 2 (8.7) | 1 (4.3) | 10 (43.5) | 4 (17.4) | 12 (52.2) | 13 (56.5) |
| 4–6 | 1 (4.2) | 4 (16.7) | 10 (41.7) | 8 (33.3) | 17 (70.8) | 22 (91.7) | |
| > 6 | 3 (5.7) | 11 (20.8) | 19 (35.8) | 27 (50.9) | 35 (66) | 45 (84.9) | |
| P value | 0.740 | 0.221 | 0.795 | 0.019 | 0.357 | 0.004 | |
| Annual bleeding rate | 1–3 | 2 (8.7) | 1 (4.3) | 10 (43.5) | 4 (17.4) | 12 (52.2) | 13 (56.5) |
| > 3 | 4 (5.2) | 15 (19.5) | 29 (37.7) | 35 (45.5) | 52 (67.5) | 67 (87) | |
| P value | 0.619 | 0.109 | 0.634 | 0.016 | 0.218 | 0.003 | |