Table 3.
Multivariable logistic regression analysis of covariates associated with various bone diseases in patients with hemophilia
| Variables | Skeletal complications | |||||
|---|---|---|---|---|---|---|
| Bone disease | Osteoporosis | Target joint | ||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Treatment* | 2.54 (0.64–10.02) | 0.182 | 0.61 (0.19–1.96) | 0.408 | 1.93 (0.49–7.58) | 0.341 |
| Age at diagnosis | 0.99 (0.95–1.04) | 0.944 | 1.06 (1.00–1.13) | 0.051 | 1.02 (0.95–1.10) | 0.436 |
| Annual bleeding rate** | 2.10 (0.40–10.97) | 0.378 | 0.69 (0.21–2.22) | 0.540 | 2.00 (0.50–8.06) | 0.325 |
| Severity of hemophilia*** | 2.94 (0.68–12.68) | 0.146 | 14.43 (1.60–129.6) | 0.017 | 10.12 (0.93–109.3) | 0.057 |
| History of hepatitis C infection | 3.18 (0.98–10.31) | 0.053 | 0.94 (0.34–2.55) | 0.909 | 3.67 (1.28–10.48) | 0.015 |
OR Odds ratio, CI Confidence interval
*Prophylaxis vs. on-demand factor replacement therapy
** > 3 bleeding/year versus 1–3 bleeding/year
***Severe hemophilia versus non-severe hemophilia