Table 4.
Human studies CAR M-based cells
| NCT number | Tumors | Phase | Macrophage source | Study type | Gene transfer | Initial year |
|---|---|---|---|---|---|---|
| 03608618 | Advanced ovarian and peritoneal mesothelioma | I | PBMCs | Clinical trial | mRNA transfection | 2018 |
| 04660929 | HER2 overexpression solid tumors | I | Primary human macrophages | Clinical trial | Adenovirus transfection | 2020 |
| 05007379 | Against organoids from early and advanced breast cancer patients | I | N/A | Cohort | N/A | 2021 |
| 05138458 | Refractory/ relapsed T-cell lymphoma | I/II |
MT-101 (Gathered from PBMCs) |
Clinical trial | mRNA transfection | 2021 |