Table 3. Cox Analysis to Assess the Relationship Between Demographic, Clinical and Therapeutic Variables with the Survival of the Participants (n = 3443) .
| Predictors Variable | Number of Patients | Number of Death (%) | Hazard Ratio (95% CI) | |
| Univariate | Multivariate | |||
| Age (y) | ||||
| < 50 | 2078 | 269 (12.9) | 1 | - |
| ≥ 50 | 1365 | 236 (17.3) | 1.45 (1.22–1.73)* | - |
| Education level | ||||
| ≥ high school diploma | 1619 | 188 (11.6) | 1 | 1 |
| < high school diploma | 1640 | 291 (17.7) | 1.8 (1.5–2.16)* | 1.57 (1.13–2.17)* |
| Marital status | ||||
| Married | 2729 | 383 (14) | 1 | 1 |
| Single/divorced/ widowed | 714 | 122 (17.1) | 1.28 (1.05–1.57)* | 1.65 (1.13–2.4)* |
| Reproductive status | ||||
| Menopausal | 2066 | 234 (17) | 1 | - |
| Premenopausal | 1377 | 271 (13.12) | 0.83 (0.7–0.99)* | - |
| Lymph node involvement | ||||
| Negative | 1024 | 82 (8.01) | 1 | 1 |
| Positive | 1834 | 352 (19.22) | 3.03 (2.38–3.85)* | 2.07 (1.38–3.09)* |
| Tumor size (cm) | ||||
| < 2 | 646 | 43 (6.66) | 1 | 1 |
| 2–5 | 1263 | 201 (15.91) | 2.37 (1.7–3.3)* | 1.52 (0.89–2.59) |
| ≥ 5 | 531 | 140 (26.37) | 5.7 (4.04–8.03)* | 2.83 (1.59–2.04)* |
| Type of surgery | ||||
| Breast preservation | 1247 | 116 (9.3) | 1 | - |
| MRM | 1582 | 301 (19) | 1.84 (1.49–2.29)* | - |
| Pathology Report | ||||
| Others | 472 | 45 (9.53) | 1 | - |
| Invasive ductal carcinoma | 2478 | 398 (16.06) | 1.58 (1.16–2.16)* | - |
| Grading of disease | ||||
| I | 231 | 30 (12.99) | 1 | - |
| II | 1202 | 180 (14.97) | 1.17 (0.8–1.73) | - |
| III | 582 | 99 (17.01) | 1.55 (1.03–2.23)* | - |
| Estrogen receptor | ||||
| Positive | 1539 | 236 (15.33) | 1 | - |
| Negative | 596 | 112 (18.79) | 1.23 (0.98–1.53) | - |
| Her2 receptor | ||||
| Negative | 1238 | 192 (15.5) | 1 | - |
| Others | 566 | 104 (18.4) | 1.21 (0.95–1.54) | - |
| Chemotherapy | ||||
| Yes | 2392 | 391 (16.3) | 1 | - |
| No | 262 | 27 (10.3) | 0.53 (0.36–0.78)* | - |
| Radiotherapy | ||||
| Yes | 2102 | 324 (15.4) | 1 | - |
| No | 334 | 55 (16.5) | 0.85 (0.64–1.13) | - |
| Hormone therapy | ||||
| Yes | 1642 | 235 (14.3) | 1 | - |
| No | 218 | 52 (23.9) | 1.48 (1.09–1.99)* | - |
*Significant statistical correlation (P < 0.05).