FIG. 6.

trans-lactam compounds can be ranked according to potency in the gel-based assay. Dose responses of compounds 1a and 3 were carried out at the concentrations indicated, from which end points can be determined. The end point is defined as the lowest concentration at which NS4B is no longer visible—in this case, 3 μM for compound 1a and 0.3 μM for compound 3. MW, molecular weight marker (in thousands).