TABLE 5.
MICs of macrolides for drug-sensitive and resistant clinical isolates of M. tuberculosisa
| Isolate resistance profile | MIC (μM)
|
|||
|---|---|---|---|---|
| CLR | RU66252 | RU69874 | RU60887 | |
| Pan sensitive (H37Rv) | 4.0 | 0.5 | 0.5 | 1.0 |
| Pan sensitive | 0.25 | 0.25 | 0.25 | 0.5 |
| Pan sensitive | 2.0 | 0.5 | 0.5 | 0.5 |
| Pan sensitive | 2.0 | 0.25 | 0.25 | 2.0 |
| Pan sensitive | 0.5 | 0.5 | 0.5 | 1.0 |
| STR | 0.125 | 0.125 | 0.25 | 0.5 |
| STR | 4.0 | 2.0 | 1.0 | 1.0 |
| INH | 16.0 | 4.0 | 4.0 | 4.0 |
| INH, RIF, STR | 2.0 | 0.5 | 0.5 | 1.0 |
| INH, RIF | 32.0 | 1.0 | 4.0 | 4.0 |
| INH, RIF, EMB, STR | 16.0 | 1.0 | 4.0 | 2.0 |
a
INH, isoniazid; RIF, rifampin; STR, streptomycin; EMB, ethambutol; CLR, clarithromycin. MABA MICs were determined by visual reading.