TABLE 3.

Mutations identified by sequencing the entire katG gene of the 29 isoniazid-resistant isolates lacking mutations causing an amino acid substitution at katG 315 or mutations in the inhA promoter region (excluding the katG 463 polymorphism)

Nucleotide position	Triplet	Codon	Amino acid change	Frequency (no. of isolates)
−1 before gene	Insertion of Ca			1
149	Deletion of A	50	Frame shift	1
321	TGG→TGA	107	Trp→stop codon	1
571	TGG→CGG	191	Trp→Arg	1
701	GGG→GAG	234	Gly→Glu	1
723	CCC→CCGa	241	Pro→Pro	2
942	ACC→ACT	314	Thr→Thr	1
1450	CGT→AGT	484	Arg→Ser	1
1469	CGC→TGC	490	Arg→Cys	1
2096	GGG→GAG	699	Gly→Gln	1

^aThese mutations occurred together in one isolate.