TABLE 2.
Toxicities of CPT1, XF70, and XF73 against fibroblasts and keratinocytes
| Compound | EC50 (μM) at the following incubation timea:
|
|||
|---|---|---|---|---|
| 1 h
|
4 h
|
|||
| Fibroblasts | Keratinocytes | Fibroblasts | Keratinocytes | |
| CPT1 | 0.1 ± 0.009 | 0.1 ± 0.002 | 0.01 ± 0.03 | 0.09 ± 0.03 |
| XF70 | 0.01 ± 0.008 | 0.09 ± 0.03 | 0.08 ± 0.02 | 0.017 ± 0.02 |
| XF73 | 0.009 ± 0.04 | 0.009 ± 0.01 | 0.009 ± 0.01 | 0.009 ± 0.009 |
a
Fibroblasts and keratinocytes were incubated with different concentrations (0 to 10 μM) of each photosensitizer and incubated for 1 or 4 h prior to illumination. The values are the averages of three independent experiments ± standard deviations.