TABLE 1.

Pharmacokinetic parameters of tigecycline in serum and blister fluid

Subject no.	Value for tigecycline in:
	Serum				Blister fluid
	Tmax (h)	Cmax (ng/ml)	AUC0-12 (ng · h/ml)	t1/2 (h)a	Tmax (h)	Cmax (ng/ml)	AUC0-12 (ng · h/ml)	t1/2 (h)
1	0.5	804	2,408	ND	6.0	1,157	1,649	9.5
2	0.5	853	2,552	47.3	3.0	194	1,932	12.6
3	0.5	864	2,356	60.5	6.0	183	1,766	13.6
4	0.5	928	2,243	45.4	1.0	223	1,731	9.7
5	0.5	967	2,073	56.6	4.0	146	1,396	9.9
6	0.5	771	2,617	ND	3.0	201	1,823	11.7
7	0.5	716	1,786	26.2	0.5	129	1,296	16.8
8	0.5	674	1,819	27.2	2.0	162	1,330	9.0
9	0.5	954	2,268	ND	1.0	177	1,583	14.2
10	0.5	662	1,730	51.0	1.0	160	1,584	10.7
Mean	0.5	819	2,185	44.9	2.8	273	1,609	11.8
SD	0.0	113	320	13.5	2.0	312	214	2.5

^aND, not determined in individual subject because of insufficient data points.