TABLE 2.
Fusidic acid susceptibilities of S. aureus strains
| S. aureus strain | Substitution(s) in EF-Ga | Fusidic acid MIC (μg/ml)b |
|---|---|---|
| T52 (clinical isolate) | A67T, P406L | 8 |
| T121 (clinical isolate) | S416F, H457Y | 64 |
| RN4220 | 0.032 | |
| RN4220/pSB2 | 0.032 | |
| RN4220/pSB2-A67T | A67T | 0.032 |
| RN4220/pSB2-P406L | P406L | 8 |
| RN4220/pSB2-A67T/P406L | A67T, P406L | 8 |
| RN4220/pSB2-S416F | S416F | 0.032 |
| RN4220/pSB2-H457Y | H457Y | 64 |
| RN4220/pSB2-S416F/H457Y | S416F, H457Y | 64 |
a
The amino acid exchanges given for the recombinant RN4220 derivatives refer to those in plasmid-encoded EF-G.
b
MICs were measured with Etest strips.