TABLE 2.
Distribution of tigecycline and minocycline MICs according to the resistance determinants in the gram-positive bacteria tested
| Species (no. of isolates) and antibiotic | Resistance genea
|
No. of isolates with MIC (mg/liter) of:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| tet(M) | tet(K) | ≤0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | |
| Staphylococcus aureus (106) | |||||||||||||
| Tigecycline | − | − | 1 | 3 | 1 | ||||||||
| + | − | 51 | 6 | ||||||||||
| − | + | 2 | 24 | 9 | 1 | 1 | |||||||
| + | + | 3 | 4 | ||||||||||
| Minocycline | − | − | 4 | 1 | |||||||||
| + | − | 32 | 20 | 4 | 1 | ||||||||
| − | + | 1 | 2 | 14 | 16 | 1 | 1 | 1 | 1 | ||||
| + | + | 2 | 4 | 1 | |||||||||
| Streptococcus pneumoniae (104) | |||||||||||||
| Tigecycline | − | − | 5 | ||||||||||
| + | − | 22 | 35 | 21 | 13 | 4 | 4 | ||||||
| Minocycline | − | − | 4 | 1 | |||||||||
| + | − | 18 | 49 | ||||||||||
a
+, present; −, absent.