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. 2023 Nov 14;10:1221620. doi: 10.3389/fcvm.2023.1221620

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© 2023 Elster, Ommer-Bläsius, Lang, Vajen, Pfeiler, Feige, Yau Pang, Böttenberg, Verheyen, Lê Quý, Chernigovskaya, Kelm, Winkels, Schmidt, Greiff and Gerdes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparing the different TCR repertoires reveals shared TCR sequences, a high correlation of the V-gene usage and several frequently used TRBV genes in AAA. (A) Legend and color code. (B) Analysis of the TCR repertoire overlap shows that in 7 instances two AAA samples contain one equal TCR. The color code in the heatmap indicates the different samples. The V-gene usage of the TCR alpha chain (C) and of the TCR beta chain (D) is correlated and hierarchical clustered between the different samples using spearman correlations. Color gradient indicates the level of correlation (blue = negative correlation, red = positive correlation). The color code on the axes indicates the different samples. (E) Distribution and frequency of TRBV genes occurring in all samples. Frequently used TRBV genes in AAA samples are TRBV3, TRBV19, and TRBV12-2+TRBV13-2 at day 7, 14 and 28. TRA, TCR alpha chain; TRAV, TCR alpha chain v gene; TRB, TCR beta chain; TRBV, TCR beta chain v gene.