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. 2023 Nov 14;10:1221620. doi: 10.3389/fcvm.2023.1221620

Figure 4.

Figure 4

Overlap of AAA-associated CDR3 sequences with public databases. (A) Venn diagram indicating the overlap of our TCR data with the public TCR databases (VDJdb and McPAS-TCR) representative for the disease MCMV. Our data shares 21 CDR3 sequences with the public databases that are associated with MCMV and 35 CDR3 sequences that are associated with other diseases. One-sided Fisher's exact test with Bonferroni correction for multiple comparisons was used to examine the overrepresentation of TCR clones in our dataset that are associated with diseases or antigens. (B) Barplot displaying the number of sequences per disease in our data. COPD, chronic obstructive pulmonary disease; Col II, collagen II; EAE, experimental autoimmune encephalomyelitis; GVD, graft vs. host disease; HSV1, herpes simplex virus 1; HIV, human immunodeficiency virus; LCMV, lymphocytic choriomeningitis virus; MCMV, murine cytomegalovirus; MuLV, murine leukemia virus; RSV, respiratory syncytial virus; SLE, systemic lupus erythematosus; VSV, vesicular stomatitis virus.