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. Author manuscript; available in PMC: 2023 Nov 29.
Published in final edited form as: Nat Rev Neurol. 2023 Apr 6;19(5):261–277. doi: 10.1038/s41582-023-00789-z

Fig. 1 |. Genetic loci associated with Alzheimer disease in genome-wide association studies of non-Hispanic white individuals.

Fig. 1 |

Manhattan plot from a study by Bellenguez and colleagues16 showing the identified genetic loci associated with Alzheimer disease in non-Hispanic white individuals. P values are two-sided raw P values derived from fixed-effect meta-analysis. The threshold for genome-wide significance (P = 5 × 10−8) is indicated by the red dashed line, and the suggestive threshold for genome-wide significance (P = 1 < 10−5) is indicated by the black dashed line. Loci are named for the closest gene to the sentinel variant for each locus. Loci newly identified by Bellenguez et al. are shown in red, whereas loci previously reported are shown in light and dark blue. Adapted from ref. 16, Springer Nature Limited.