. Author manuscript; available in PMC: 2023 Nov 29.

Published in final edited form as: Nat Rev Neurol. 2023 Apr 6;19(5):261–277. doi: 10.1038/s41582-023-00789-z

Table 1 |.

Genetic loci with a P value of ≤10⁻⁷ identified in GWAS of AD in African Americans

SNP	Position (hg38)	Closest gene	Minor allele	MAF	Ref.
rs115684722	1:23,224,0417	SIPA1L2	T	0.003	36
rs2633682	3:104,690,364	ALCAM	A	0.338	36
rs168193	3:5,260,392	EDEM1	G	0.267	36
rs145848414	5:174,587,111	NSG2/MSX2	A	0.0416	38
rs184179037	5:37,483,838	WDR70	T	0.0008	36
rs7748513	6:41,160,234	TREM2 ^a	A	0.459	36
rs112404845	7:51,510,325	COBL	T	0.01	206
rs569584007	11:43,145,292	API5 ^b	G	0.0023	36
rs115816806	11:76,830,796	ACER3	G	0.0083	36
rs75739461	12:18,318,612	PIK3C2G	A	0.0151	36
rs9516245	13:93,507,547	GPC6	C	0.0189	36
rs570487962	15:97,449,455	ARRDC4/IGF1R	C	0.0008	36
rs79537509	16:8,238,399	RBFOX1 ^a	A	0.007	36
rs115550680	19:1,050,421	ABCA7 ^a	G	0.0681	38
rs157591	19:44,920,677	APOE ^a	A	0.1422	38
rs3745495	19:50,021,075	VRK3 ^c	G	0.0877	36

A P value cut-off of ≤10⁻⁷ indicates loci suggestive of genome-wide significance. GWAS, genome-wide association study; hg38, Genome Reference Consortium Human Build 38; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.

Locus is also observed in non-Hispanic white individuals.

5 Mb apart from but not in linkage disequilibrium with CELF1/SPI1 locus observed in non-Hispanic white individuals¹⁶.

1.7 Mb apart from but not in linkage disequilibrium with CD33 observed in non-Hispanic white individuals¹⁷.