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CPT resistance mutations in L. donovani and human Topo-I with their corresponding residues
| Residue type |
L. donovani mutation
|
Human mutation
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| G185R | D325E | N722S | F361S | R364H | G363C | E418K | D533G | G503S | T729A | A653P | |
| Human | G359 | D500 | |||||||||
| L. donovani | A579 | F187 | R190a | G189 | D244 | D353a | G328 | A586 | Y474 | ||
Amino acid residues predicted to interact with CPT in L. donovani based on the human Topo-I crystal structure.
