TABLE 3.

Effect of TRB concentration on VRC activity as determined by the checkerboard and Etest methods

Strain	VRC MIC (μg/ml) with TRB concn of:
	0		1 μg/ml		2 μg/ml		8 μg/ml
	M27-A2	Etest	Checkerboard	Etest	Checkerboard	Etest	Checkerboard	Etest
C. albicans
EU-62	>2	>32	0.002	0.002	0.03*	0.004*	0.002*	0.008*
EU-78	0.008	0.008	0.002*	0.008*	0.002*	0.004*	0.002*	0.008*
EU-80	>2	>32	0.002-0.06*	0.002	0.002*	0.002*	0.002*	0.016*
EU-87	>2	>32	0.002*	0.016*	0.002*	0.016*	0.002*	0.012*
EU-170	>2	>32	0.016	0.016	0.03*	0.012*	0.002*	0.012*
C. glabrata
EU-12	>2	>32	0.5	NDb	0.12	0.5	0.12	0.5
EU-38	>2	16	>2	ND	>2	0.5	1	0.5
EU-68	>2	8	2	ND	2	8	1	2
EU-151	0.5	2	2	ND	2	1	0.5	0.25
EU-195	>2	0.5	0.5	ND	0.25	0.38	0.12	0.12
C. tropicalis
EU-43	0.12	0.06	2	ND	0.25	0.12	0.002	0.12
EU-240	>2	0.19	>2	ND	0.25	0.38	0.25	0.5
EU-245	1	0.06	0.12	ND	0.12	0.12	0.016	0.047
EU-255	>2	0.25	>2	ND	2	0.25	0.016	0.5
EU-264	0.03	0.12	0.016	ND	0.016	0.06	0.016	0.19*
C. krusei
EU-123	0.5	0.25	0.5	ND	0.5	0.19*	0.5*	0.25*
CK-1	0.5	0.25	0.25	ND	0.25	0.25*	0.25*	0.12*
CK-2	1	0.5	0.5	ND	0.5	0.5*	0.5*	0.5*
CK-3	0.5	0.25	0.25	ND	0.25	0.25*	0.25*	0.25*
CK-4	0.5	0.25	0.5	ND	0.5	0.25*	0.5*	0.25*

^aAsterisks indicate the minimum drug concentration that produced 100% growth inhibition.

^bND, not determined.