Table 3.

Results of multivariate analysis in nivolumab cohort for association with overall survival.

Texture Features	p-value	Hazard Ratio (95% CI)
Surface-to-mass ratio	0.325	0.984 (0.952-1.017)
Average Grey value	0.594	0.998 (0.992-1.004)
2D kurtosis	0.040	0.996 (0.992-1.0)
Laboratory Values
Neutrophil-to-lymphocyte ratio	0.117	1.046 (0.989-1.106)
Clinical Features
ECOG Performance Status	<0.001	2.394 (1.663-3.447)
Female sex	0.057	0.688 (0.468-1.011)

Hazard ratios are reported for selected variables. Age, histology, and number of prior therapies were excluded and a second multivariable analysis was performed with the remaining variables. Texture features, NLR, ECOG, and sex were selected for inclusion in the predictive model, as described in Statistical Methods.