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. 2023 Nov 15;13:1225720. doi: 10.3389/fonc.2023.1225720

Table 4.

Baseline clinical characteristics for human cohort receiving pembrolizumab.

Patient Race
White 24 51.72%
Black 2 4.76%
Hispanic 15 35.71%
Asian 1 2.38%
Total 42 100%
Patient Sex
Male 22 52.38%
Female 20 47.62%
Total 42 100%
Body Mass Index
Median 25.27
Mean 25.89
Age (years)
Median 71
Mean 70.69
Smoking History
Never 3 7.14%
<15 pack years 7 16.67%
15-30 pack years 13 30.95%
>30 pack years 19 45.24%
Total 42 100%
Pre-Treatment ECOG PS
0 6 14.29%
1 32 76.19%
2 3 7.14%
3 1 2.38%
Total 42 100%
Pathology
Adenocarcinoma 34 80.95%
Squamous Cell Carcinoma 6 14.29%
Adenosquamous 1 2.38%
Bronchoalveolar 0 0%
NSCLC, NOS 1 2.38%
Total 42 100%
Number of Prior Systemic Therapies1
0 17 40.48%
1 20 47.62%
2 4 9.52%
3 1 2.38%
4 0 0%
Total 42 100%
Mean 0.738
Median 1
Relapsed or de novo Metastatic Disease
Metachronous 12 28.57%
Synchronous 30 71.43%
PD-L1 Expression Status
High (>50%) 24 61.54%
Low (1-49%) 10 25.64%
Negative (<1%) 5 12.82%
Missing 3
Targetable Mutation Status
KRAS 2 6.90%
EGFR 4 13.79%
ALK 1 3.45%
MET 2 6.90%
BRAF V600E 1 3.45%
None 19 65.52%
Missing 13
Daily Steroid Use
Taking 7 16.67%
Median Prednisone Equivalent Dose (mg) 20
Blood Count Tests Median Mean
NLR 5.16 6.46
PLR 220.97 248.30
NMR 9.39 12.71
LMR 2.01 2.30
Primary Tumor Size (cc)
Median 11.10
Mean 62.30
Nodal Disease at Time of ImT
Yes 31 73.81%
No 11 26.19%
Anatomic M Stage
M1a 14 33.33%
M1b 5 11.90%
M1c 23 54.76%
Overall Stage
IVA 19 45.2%
IVB 23 54.8%
Prognostic Nutritional Index
Median 43.6
Mean 44.27

1 Excluding Avastin.