TABLE 1.
GM MICs and MIC ranges for the 34 isolates by the indicated methoda
| Species (no. of strains) | Method | GM MIC in μg/ml (range)
|
||||
|---|---|---|---|---|---|---|
| Caspofungin | Fluconazole | Itraconazole | Flucytosine | Amphotericin B | ||
| C. albicans (17) | M27-A2 (24 h) | 0.806 (0.06->16) | 0.298 (0.12-64) | 0.059 (0.03-16) | 0.144 (0.12-1) | 0.800 (0.12-2) |
| M27-A2 (48 h) | 1.126 (0.06->16) | 0.372 (0.12-64) | 0.065 (0.03-16) | 0.206 (0.12-4) | 1.54 (0.25-4) | |
| RPMI-G (24 h) | 0.899 (0.03->16) | 0.243 (0.12-64) | 0.042 (0.03-0.5) | 0.164 (0.12-0.5) | 0.53 (0.12-4) | |
| SYO (24 h) | 0.327 (0.03->16) | 0.546 (0.12-256) | 0.08 (0.03-16) | 0.086 (0.03-4) | 1.78 (1-2) | |
| SYO (48 h) | 0.669 (0.03->16) | NDb | ND | ND | ND | |
| C. parapsilosis (5) | M27-A2 (24 h) | 1.180 (0.25-4) | 0.292 (0.12-1) | 0.057 (0.03-0.25) | 0.132 (0.12-0.25) | 1 (0.25-4) |
| M27-A2 (48 h) | 1.84 (1-16) | 0.46 (0.12-1) | 0.07 (0.03-0.25) | 0.16 (0.12-0.5) | 1.95 (0.5-4) | |
| RPMI-G (24 h) | 1.39 (0.5-16) | 0.32 (1-8) | 0.05 (0.06-0.25) | 0.18 (0.12-2) | 0.64 (0.25-2) | |
| SYO (24 h) | 0.59 (0.25-4) | 1.14 (0.12-2) | 0.11 (0.008-0.25) | 0.14 (0.03-0.25) | 1.51 (0.5-2) | |
| SYO (48 h) | 1.39 (0.25-16) | ND | ND | ND | ND | |
| C. krusei (3) | M27-A2 (24 h) | 0.658 (0.12-2) | 12.670 (1-32) | 0.299 (0.03-1) | 8 (4-16) | 2 (1-4) |
| M27-A2 (48 h) | 0.72 (0.12-2) | 27.86 (4-64) | 0.46 (0.25-1) | 10.08 (4-16) | 2.64 (2-4) | |
| RPMI-G (24 h) | 0.95 (0.03-2) | 19.25 (1-32) | 0.26 (0.06-1) | 9.19 (4-64) | 0.72 (0.5-4) | |
| SYO (24 h) | 0.42 (0.03-0.5) | 46.3 (32-64) | 0.42 (0.25-0.5) | 9.19 (8-16) | 3.03 (2-4) | |
| SYO (48 h) | 0.83 (0.12-2) | ND | ND | ND | ND | |
| C. glabrata (3) | M27-A2 (24 h) | 0.376 (0.03-2) | 3.482 (2-16) | 0.272 (0.06-1) | 0.12 (0.12) | 1.587 (1-4) |
| M27-A2 (48 h) | 0.41 (0.03-2) | 4.19 (1-32) | 0.50 (0.06-4) | 0.13 (0.12-0.25) | 2.00 (1-4) | |
| RPMI-G (24 h) | 0.47 (0.03-2) | 3.32 (1-16) | 0.19 (0.06-1) | 0.14 (0.12-0.25) | 0.57 (0.12-2) | |
| SYO (24 h) | 0.14 (0.03-0.25) | 13.3 (4-128) | 1.15 (0.5-16) | 0.03 (0.03-0.03) | 2.00 (2-2) | |
| SYO (48 h) | 0.31 (0.12-0.5) | ND | ND | ND | ND | |
| C. tropicalis (2) | M27-A2 (24 h) | 0.435 (0.25-1) | 0.38 (0.25-4) | 0.098 (0.03-0.5) | 0.149 (0.12-0.25) | 1.515 (1-2) |
| M27-A2 (48 h) | 0.54 (0.25-1) | 0.54 (0.25-4) | 0.19 (0.03-1) | 0.25 (0.12-0.5) | 2.14 (1-4) | |
| RPMI-G (24 h) | 0.50 (0.06-1) | 0.29 (0.12-0.25) | 0.06 (0.03-0.25) | 0.15 (0.12-0.5) | 0.66 (0.25-2) | |
| SYO (24 h) | 0.14 (0.03-0.5) | 0.66 (0.25-2) | 0.16 (0.06-0.25) | 0.03 (0.03-0.06) | 2.00 (2-2) | |
| SYO (48 h) | 0.34 (0.06-8) | ND | ND | ND | ND | |
| C. guilliermondii (2) | M27-A2 (24 h) | 0.754 (0.12-4) | 0.87 (0.25-2) | 0.174 (0.03-0.5) | 0.12 (0.12) | 1.741 (1-4) |
| M27-A2 (48 h) | 0.87 (0.12-2) | 1.23 (0.25-4) | 0.31 (0.03-1) | 0.13 (0.12-0.25) | 1.87 (1-4) | |
| RPMI-G (24 h) | 0.81 (0.25-2) | 0.76 (0.25-2) | 0.13 (0.03-0.5) | 0.14 (0.12-0.25) | 0.75 (0.12-4) | |
| SYO (24 h) | 0.16 (0.03-0.5) | 2.3 (1-4) | 0.25 (0.06-0.5) | 0.03 (0.03-0.06) | 1.83 (1-2) | |
| SYO (48 h) | 0.32 (0.06-2) | ND | ND | ND | ND | |
| C. famata (1) | M27-A2 (24 h) | 0.435 (0.25-1) | 0.329 (0.25-0.5) | 0.091 (0.03-0.5) | 0.12 (0.12) | 1.515 (1-2) |
| M27-A2 (48 h) | 0.5 (0.25-1) | 0.43 (0.12-1) | 0.16 (0.03-0.5) | 0.12 (0.12) | 2.30 (2-4) | |
| RPMI-G (24 h) | 0.5 (0.25-1) | 0.22 (0.06-0.5) | 0.05 (0.03-0.12) | 0.14 (0.12-0.25) | 0.66 (0.25-4) | |
| SYO (24 h) | 0.12 (0.03-0.25) | 0.87 (0.5-2) | 0.16 (0.12-0.25) | 0.03 (0.03-0.06) | 2.00 (2-2) | |
| SYO (48 h) | 0.25 (0.12-0.5) | ND | ND | ND | ND | |
| C. lusitaniae (1) | M27-A2 (24 h) | 0.5 (0.5) | 0.287 (0.25-0.5) | 0.103 (0.03-0.5) | 0.12 (0.12) | 0.569 (0.12-2) |
| M27-A2 (48 h) | 0.5 (0.5) | 0.43 (0.25-1) | 0.04 (0.03-0.12) | 0.19 (0.12-0.25) | 1.14 (0.25-4) | |
| RPMI-G (24 h) | 0.5 (0.5) | 0.28 (0.12-1) | 0.04 (0.03-0.25) | 0.12 (0.12-0.12) | 0.66 (0.5-1) | |
| SYO (24 h) | 0.08 (0.03-0.12) | 0.76 (0.5-4) | 0.18 (0.06-16) | 0.05 (0.03-0.06) | 1.32 (1-2) | |
| SYO (48 h) | 0.10 (0.06-0.12) | ND | ND | ND | ND | |
| All strains (25) | M27-A2 (24 h) | 0.728 (0.03->16) | 0.560 (0.12-64) | 0.090 (0.03-16) | 0.203 (0.12-16) | 1.044 (0.12-4) |
| M27-A2 (48 h) | 0.957 (0.03->16) | 0.772 (0.12-64) | 0.15 (0.03-16) | 0.260 (0.12-16) | 1.769 (0.25-4) | |
| RPMI-G (24 h) | 0.847 (0.03->16) | 0.507 (0.06-64) | 0.07 (0.03-1) | 0.230 (0.12-64) | 0.573 (0.12-4) | |
| SYO (24 h) | 0.228 (0.03->16) | 1.345 (0.12-256) | 0.18 (0.008-16) | 0.109 (0.03-16) | 1.88 (0.5-4) | |
| SYO (48 h) | 0.603 (0.03->16) | ND | ND | ND | ND | |
a
The reference and QC strains are not included.
b
ND, not determined.