TABLE 2.

Influence of the methods tested on activity of caspofungin against Merck reference strains

Strain	GM MIC (range) in μg/ml
	M27-A2		RPMI-G		SYO
	24 h	48 h	24 h	48 h	24 h	48 h
CAI4	0.38 (0.25-0.5)	0.38 (0.25-0.5)	0.22 (0.03-0.5)	0.53 (0.25-0.5)	0.21 (0.12-0.25)	0.38 (0.25-0.5)
CAI4R1a	3.48 (1-16)	9.19 (4->16)	5.27 (1->16)	8.00 (4->16)	4 (2->16)	12.12 (4->16)
T25a	5.28 (4-16)	9.19 (4->16)	6.96 (4-16)	11.31 (4->16)	6.96 (4-8)	12.12 (4->16)
T26a	6.96 (4-16)	12.12 (4->16)	6.96 (4-16)	13.45 (4->16)	6.06 (4-8)	16 (16)
T28	0.33 (0.12-0.25)	0.33 (0.12-0.25)	0.21 (0.06-0.5)	0.50 (0.5)	0.08 (0.06-0.12)	0.16 (0.06-0.25)
T32	0.28 (0.12-0.5)	1.74 (0.25-16)	0.16 (0.03-0.5)	0.35 (0.25-0.5)	0.07 (0.03-0.12)	0.49 (0.12-16)
NR2a	4 (2-16)	6.96 (4-16)	4.59 (2-16)	5.65 (4->16)	1.13 (1-2)	6.97 (4-16)
NR3a	6.96 (4-16)	9.19 (4->16)	8 (4-16)	8.00 (4-16)	4 (4)	12.12 (4->16)
NR4a	2 (2)	2.29 (2-4)	4 (2-16)	5.28 (3->16)	2 (2)	6.06 (4-16)

^aCaspofungin mutant with low caspofungin susceptibility.