TABLE 3.
Relationship between A-to-G mutations of clarithromycin-resistant H. pylori isolates and the failed eradication after clarithromycin-based therapy against 114 patients with gastric or duodenal ulcers
| Isolatea (no.) | No. of patientsb (%) | No. of isolates with eradication failure (%) | MIC (μg/ml)b
|
|
|---|---|---|---|---|
| Amoxicillin | Clarithromycin | |||
| Wild type (91) | 91 (79.83) | 0 (0.00) | 0.016-0.063 (S) | 0.031-0.125 (S) |
| A2142G (20) | 20 (17.54) | 20c (17.54) | 0.031-0.125 (S) | 32->256 (R) |
| A2143G (3) | 3 (2.63) | 3c (2.63) | 0.016-0.125 (S) | 4-128 (R) |
a
Sequence and PCR-RFLP analyses of the 23S rRNA gene from each H. pylori isolated from each patient revealed mutations (A→G) at residues 2142 and 2143.
b
Results presented for each isolate before treatment are the same as those after treatment. Abbreviations: S, susceptible; R, resistant.
c
Significantly different (P = 0.0001) from the value for wild-type isolates.