Table 1 Role and potential mechanism of HIF-1α in HCC

Function	Related genes and pathways	Ref.
Migration	Increase TM4SF1-AS1 and TM4SF1	[32]
Invasion	HIF-1α/IL-8/NF-κB axis	[33]
Proliferation	Activate KDM4A-AS1/KPNA2/AKT pathway	[34]
Autophagy	YTHDF1/ATG2A/ATG14 axis	[35]
Angiogenesis	Upregulation of Bclaf1 expression	[36]
EMT	TGM2/VHL/HIF-1α axis	[29]
Glycolysis	TFBM2/SIRT3/HIF-1α signal pathway	[37]
Lipid metabolism	FABP5/HIF-1α axis	[31]
Drug resistance	PFKFB3/HIF-1α feedback loop	[38]