Table 2 Major research advances in ncRNA and HIF-1α in cancer

ncRNAs	Cancer	Regulatory mechanisms	Functions	Ref.
miRNA
miR-671-5p	Oophoroma	Inhibiting HIF-1α expression via activating HDAC5	Proliferation and apoptosis	[44]
miR-29a	HCC	Supressing HIF-1α expression	Proliferation	[45]
miR-142-3p	HCC	Inhibiting PI3K/AKT/HIF-1α signaling	Invasion and apoptosis	[46]
miR-138-5p	HCC	Targeting HIF-1α and regulating its expression	Vascular mimicry	[47]
miR-322/424	Cirrhosis	Inducing HIF-1α protein expression	Angiogenesis and migration	[48]
miR-200c	HCC	Downregulating the transcriptional activity of HIF-1α		[49]
lncRNA
LINC00649	Breast cancer	Maintaining the stability of HIF-1α	Metastasis	[50]
NORAD	Colorectal cancer	Acting as miR-495-3p sponge to adjust HIF-1α	Angiogenesis and chemotherapy resistance	[51]
FAM83A-AS1	Lung adenocarcinoma	Suppressed combination of HIF-1α and VHL leads to HIF-1α accumulation	Proliferation and migration	[52]
LINC00525	Colorectal cancer	Activating HIF-1α via miR-338-3p/UBE2Q1/β-catenin axis	Proliferation	[53]
PAARH	HCC	Promoting HIF-1α/VEGF signaling	Progression and angiogenesis	[54]
HIFAL	Breast cancer	Enhancing HIF-1α transactivation	Proliferation	[55]
MAPKAPK5-AS1	HCC	Adjusting HIF-1α expression via PLAGL2	Progression	[56]
circRNA
circ_03955	Pancreatic cancer	Promoting HIF-1α through sponging miR-3662 expression	Tumorigenesis and Warburg effect	[57]