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. 2023 Nov 22;623(7989):1017–1025. doi: 10.1038/s41586-023-06639-8

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© The Author(s) 2023, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a, Representative micrograph and b, representative 2D classes for the CD4-BG505 HT1 complex. c, Workflow of single-particle cryo-EM data processing. Class I shows one CD4 bound to a closed, prefusion conformation of HT1. Class II shows density for one CD4 molecule bound to HT1 and weak density for an additional bound CD4 (red arrow). The class II density map may represent an average of HT1 Envs bound to one or two CD4 molecules. We were unable to further separate these particles into different subclasses. Class III resembles an unliganded, closed prefusion Env trimer. d, Fourier shell correlation (FSC) plots of the final reconstructions for CD4-BG505 HT1 classes I, II, and III.