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. 2023 Nov 22;623(7989):1017–1025. doi: 10.1038/s41586-023-06639-8

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© The Author(s) 2023, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, Representative micrograph and b, representative 2D classes for the CD4-BG505 HT2 complex. c, Workflow of single-particle cryo-EM data processing. d, Fourier shell correlation (FSC) plot of the final reconstruction for CD4-BG505 HT2 classes I, II, and III. e, Side and top-down views of superimposed CD4-BG505 HT1 class I and CD4-BG505 HT2 class II single-particle cryo-EM density maps. The densities for CD4 overlap extensively, thus obscuring the purple density for CD4 in the BG505 CD4-HT2 map.