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. 2023 Nov 22;623(7989):1026–1033. doi: 10.1038/s41586-023-06762-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a–e Local resolution estimation using ResMap software for the structures of the Env-CD4 complex. The structures and ResMap histograms of the consensus average (a), Env trimer bound to one CD4 molecule (b), Env trimer bound to two CD4 molecules (c), Env trimer bound to three CD4 molecules (d) and unliganded Env trimer from the same dataset (e) are shown. Subtomogram averages are coloured according to the local resolution as indicated on the scale on the right. f Fourier shell correlation (FSC) curves for cryo-ET masked subtomogram averages with FSC = 0.5 as the cutoff value. g–h. The distribution of orientations for aligned Env particles. The unliganded Env particles are evenly distributed across all orientations (g). The Env particles bound to CD4 molecules showed reduced numbers of top-view and bottom-view particles (h). This is likely because the Env-CD4 complexes are located at the interface between two viruses, resulting in a higher occurrence of side-view orientations.