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. 2023 Nov 17;9(11):e21893. doi: 10.1016/j.heliyon.2023.e21893

Fig. 2.

Fig. 2

THP-1 MΦ were incubated with increasing concentrations of SARS-CoV-2-ECD for 6h and 24h. IL-6 RNA (A) and (B) protein levels in supernatants were quantified by qRT-PCR and ELISA, respectively; C: qRT-PCR analysis of IL-6 in THP-1 MΦ incubated with TLR4 ligand LPS (10 ng/mL), with SARS-CoV-2-ECD (100 μg/mL), with and without the TLR4 inhibitor TAK-242 (10 μM) for 24h. *P < 0.05, ***P < 0.001; n = 4. Graphs show mean ± SD (TLR4: toll-like receptor 4; SARS-CoV-2-ECD: Severe acute respiratory syndrome coronavirus 2 ectodomain).