Fig. 5.

A: GO enrichment analysis of THP-1 MΦ infected with viable SARS-CoV-2 (Wuhan-Hu-1, MOI 0.005) with and without TLR4 inhibitor TAK-242 (10 μM). Blue-coloured dots indicate genes downregulated by TAK-242. B: Volcano plot of differentially expressed genes in THP-1 MΦ infected with viable SARS-CoV-2 (Wuhan-Hu-1, MOI 0.005) and treated with the TLR4 inhibitor TAK-242 (10 μM), highlighting downregulated genes of the NF-κB signalling pathway (KEGG database). (fold-change cut-off: 1.5, adjusted p-value cut-off: 0.01) (NS: not significant; FC: fold-change)