| Authors |
Year |
Country |
Findings |
| Poornachandra et al., [1] |
2022 |
India |
Patients with retinal dystrophies may benefit from improved care in the future, as new genetic diagnostic techniques and clinical studies show encouraging results. |
| Kannabiran C, [2] |
2019 |
Singapore |
The rod and cone-dominated diseases are classified as either stationary or progressing. These disorders are further grouped based on their manner of inheritance. |
| Fahim A, [3] |
2018 |
USA |
Recent developments in imaging technologies, DNA sequencing, gene therapy, and stem cell biology are currently under investigation and stem cell therapeutics. |
| Ferrari et al., [5] |
2011 |
Italy |
The genetics of RP is complicated by the vast variation of the condition. It is discussed which genes are implicated in the formation of RP and how mutations may lead to retinal degeneration. |
| Michaelides et al., [6] |
2003 |
UK |
Enhanced understanding of the mechanics of hereditary macular dystrophy, which aided in the refinement of diagnosis, illness categorization, and prognosis, as well as enhanced genetic counselling |
| Prelich G, [8] |
2012 |
USA |
The many mechanisms of overexpression employed for reagents accessible in numerous species, as well as the significance of overexpression to human illness, are discussed. |
| Tolone et al., [9] |
2019 |
Europe |
It discusses how major development efforts would go into translating new drugs or biomarkers based on cGMP signaling, along with the drug delivery technology that goes with them. |
| Megaw et al., [10] |
2015 |
USA |
Key models used to test and treat RPGR illness and imply that gene augmentation treatment. Cell replacement treatment based on retinal progenitor cells is a longer-term promise claim. |
| Veltel et al., [11] |
2009 |
UK |
RPGR and RP2, the two gene products, were discussed, and an effort was made to link the genetic information of the patients with the functional information of the corresponding proteins. |
| Lu et al., [12] |
2021 |
USA |
Vascular alterations were shown to be significantly affected by OCTA in contrast to healthy controls. The abnormalities were associated with both choroidal atrophy and loss of central vision. |
| Scalabrino et al., [13] |
2022 |
UK |
Cone and rod medicine are examined because gene remedies for rod degenerative illnesses are likely to prolong cone-mediated vision even in the event that cone shape and density change. |
| Lang et al., [14] |
2019 |
USA |
The onset of RP has been connected to vascular abnormalities. Although PR degeneration is not primarily caused by vascular abnormalities in the fovea and parafovea |
| Kukreja et al., [15] |
2012 |
USA |
There is a discussion on the significance of the cGMP pathway. A key intracellular second messenger that controls a variety of tissue and cellular reactions. |
| Rivolta et al., [16] |
2002 |
USA |
Clinically and genetically, retinitis pigmentosa (RP) and related disorders differ. A large number of genes connected to various diseases are addressed. |
| Natarajan S, [17] |
2011 |
USA |
Concerns have been expressed concerning the possible repercussions of injecting a virus into the eye, as well as the safety of vectors. |
| Becherucci et al., [18] |
2023 |
USA |
The expanding number of current clinical trials investigating the feasibility and effectiveness of various strategies in treating RP heralds a new era in the treatment of uncommon disorders. |
| Daiger et al., [19] |
2013 |
USA |
Existing strategies for RP gene identification and mutation detection risks and outstanding issues. |
| Wright et al., [20] |
2010 |
USA |
The genetic and mechanical causes of PR cell death-induced retinal degeneration. |
| Moiseyev et al., [21] |
2005 |
USA |
The discovery of RPE65's isomerohydrolase fills a critical gap for understanding of the visual cycle. |
| Hamel CP, [22] |
2007 |
USA |
Management seeks to delay the degenerative process, cure problems, and assist patients in coping with the social and psychological consequences of blindness. |
| Digre and Brennan, [23] |
2012 |
USA |
Clinical features and diseases related with photophobia, the anatomy and physiology of this condition, and a practical approach to diagnosis and therapy. |
| Hartong et al., [24] |
2006 |
USA |
The results of controlled studies of dietary interventions to decrease illnesses, Newly discovered genes, research, and urgent cures are all greatly awaited. |
| Sugawara et al., [25] |
2010 |
USA |
The significant relationship between peripheral visual field loss and vision-related quality of life score determines the degree of visual field loss. |
| Raharja and Whitefield, [26] |
2022 |
USA |
A thorough first investigation is essential in determining the urgency of the recommendation. |
| Muniz et al., [27] |
2007 |
USA |
Underlines the importance of understanding how cone photoreceptors maintain ability to detect light |
| Maguire et al., [28] |
2021 |
USA |
Considerations for Luxturna administration were discussed, as well as how the Luxturna experience may lead to future gene-based therapeutics for blindness. |
| Palczewski K, [29] |
2010 |
USA |
Pharmacological vision recovery holds great potential for the development of improved therapies for those who are on the verge of blindness or have lost all of their sight. |
| Wu et al., [30] |
2023 |
USA |
This included categorization, epidemiology, clinical symptoms, prognosis, and traditional treatments. |
| Sahel et alo., [31] |
2014 |
USA |
Progress toward IRD therapeutic strategies, as well as advancements in the pathophysiological processes and technology breakthroughs. |
| MacLaren et al., [32] |
2016 |
USA |
Stem cell-derived transplants were evaluated to relieve, reverse, and restore disease processes. |
