Table 1.
MR analyses of the causal effect of mtDNA-CN on IBDs.
| Trait | SNP | MR-Egger | Weighted median | IVW/WM | MR-PRESSO | Pleiotropy | Q | Heterogeneity | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | Global test P | P | P | |||
| Instrumental variables 1 | 55 | ||||||||||
| IBD | 0.72 (0.31–1.65) | 0.4366 | 0.87 (0.49–1.54) | 0.6308 | 1.10 (0.74–1.64) | 0.6360 | 0.065 | 0.256 | 55.47 | 0.080 | |
| CD | 2.00 (0.37–10.83) | 0.4242 | 1.55 (0.50–4.77) | 0.4415 | 2.85 (1.31–6.22) | 0.0086 | 0.076 | 0.646 | 59.24 | 0.076 | |
| UC | 0.50 (0.20–1.25) | 0.1466 | 0.70 (0.67–1.34) | 0.1943 | 0.74 (0.48–1.16) | 0.1943 | 0.247 | 0.336 | 45.97 | 0.274 | |
| Instrumental variables 2 | 47 | ||||||||||
| IBD | 1.59 (0.46–5.49) | 0.4651 | 0.72 (0.42–1.25) | 0.2469 | 1.15 (0.77–1.71) | 0.4946 | 0.164 | 0.587 | 47.00 | 0.178 | |
| CD | 10.29 (0.84–125.51) | 0.0753 | 1.47 (0.46–4.67) | 0.5159 | 1.61 (0.70–3.69) | 0.5159 | 0.102 | 0.132 | 51.38 | 0.107 | |
| UC | 0.65 (0.17–2.52) | 0.5384 | 0.77 (0.41–1.45) | 0.4150 | 0.81 (0.52–1.28) | 0.3757 | 0.755 | 0.732 | 29.81 | 0.757 | |
| Instrumental variables 3 | 78 | ||||||||||
| IBD | 0.63 (0.33–1.22) | 0.1735 | 0.89 (0.55–1.46) | 0.6537 | 0.88 (0.63–1.23) | 0.4673 | 0.148 | 0.247 | 66.32 | 0.163 | |
| CD | 2.18 (0.60–7.87) | 0.2397 | 1.16 (0.44–3.10) | 0.7638 | 1.97 (1.04–3.70) | 0.0486 | 0.205 | 0.861 | 68.25 | 0.217 | |
| UC | 0.55 (0.26–1.16) | 0.1238 | 0.72 (0.39–1.33) | 0.2965 | 0.73 (0.50–1.06) | 0.0989 | 0.255 | 0.404 | 60.97 | 0.302 | |