Table 2.
Univariable and multivariable binary logistic regression models for predictors of prolonged hospitalization solely to complete intravenous (iv) antifungal therapy (AF Tx) compared to patients without prolonged hospitalization to complete iv AF Tx in 30 day survivors (n = 383)
| Variable | Univariable odds ratio | 95% CI | p-value |
|---|---|---|---|
| Demographics | |||
| Male, Sex | 1.32 | 0.80–2.19 | 0.281 |
| Advanced Age (per 10 years) | 0.79 | 0.58–1.06 | 0.111 |
| Coexisting conditions | |||
| BMI ≥ 30 | 1.00 | 0.53–1.92 | 0.989 |
| Solid organ transplantation | 1.90 | 0.46–7.76 | 0.373 |
| Haematological/oncological | |||
| malignancy | 0.68 | 0.40–1.14 | 0.144 |
| Neutropenia (< 500/µL) | 0.35 | 0.18–0.70 | 0.002 |
| Major surgery including abdominal | |||
| surgery | 0.47 | 0.25–0.90 | 0.022 |
| Diabetes mellitus (type I or II) | 0.93 | 0.51–1.70 | 0.817 |
| Clinical factors | |||
| Intensive care unit admission | 0.48 | 0.27–0.86 | 0.013 |
| Catheter related bloodstream infection | 0.22 | 0.09–0.52 | < 0.001 |
| Extracorporeal membrane oxygenation | 0.53 | 0.06–4.34 | 0.552 |
| TPN | 0.31 | 0.14–0.67 | 0.003 |
| Charlson Comorbidity Index | 0.96 | 0.89–1.05 | 0.376 |
| Candida spp. (n)° | |||
| C. albicans (165) | 0.94 | 0.57–1.55 | 0.821 |
| C. glabrata (90) | 1.90 | 1.11–3.25 | 0.019 |
| C. parapsilosis (54) | 0.26 | 0.09–0.75 | 0.012 |
| C. tropicalis (20) | 0.64 | 0.18–2.26 | 0.492 |
| C. krusei (9) | 1.07 | 0.22–5.24 | 0.936 |
| C. auris (9) | 1.90 | 0.46–7.76 | 0.373 |
| C. dubliniensis (8) | 0.53 | 0.06–4.34 | 0.552 |
| Other Candida Species (10)* | 1.01 | 0.97–1.06 | 0.491 |
| Clinical course (i.e., not baseline variables) | |||
| Mixed fungal infections | 1.00 | 0.57–1.76 | 0.992 |
| Infection consultation (ID or microbiology) | 1.41 | 0.68–2.92 | 0.356 |
| Treatment | |||
| Initial echinocandin treatment | 2.61 | 1.47–4.62 | < 0.001 |
| Stepdown to fluconazole | 1.30 | 0.79–2.14 | 0.299 |
| Variables | Multivariable odds ratio | 95% CI | p-value |
|---|---|---|---|
| Age | 0.78 | 0.56–1.08 | 0.131 |
| Hematological malignancy | 1.42 | 0.64–3.12 | 0.389 |
| Neutropenia | 0.25 | 0.09–0.67 | 0.006 |
| Major surgery | 0.62 | 0.31–1.27 | 0.192 |
| Intensive care unit | 0.45 | 0.24–0.85 | 0.014 |
| Catheter related bloodstream infection | 0.22 | 0.09–0.56 | 0.002 |
| Total parenteral nutrition | 0.31 | 0.13–0.70 | 0.005 |
| C. glabrata | 1.74 | 0.95–3.20 | 0.075 |
| C. parapsilosis | 0.28 | 0.09–0.85 | 0.025 |
| Initial echinocandin treatment | 2.87 | 1.55–5.32 | < 0.001 |
°Candida species not specified (n = 18).
*Others include: C. rugosa (n = 3), C. pelliculosa (n = 2), C. lusitaniae (n = 2), C. inconspicua (n = 1), C. guilliermondi (n = 1), and C. digboiensis (n = 1).