Table 2.
Hemolytic activity (HC50 [µg/mL]) and selectivity indexes
| Peptide | HC50 | Selectivity index (SI) | ||||||
|---|---|---|---|---|---|---|---|---|
| E. faecium | S. aureus | K. pneumoniae | A. baumannii | P. aeruginosa | K. aerogenes | C. glabrata | ||
| 1M | 477.61 ± 28.02 | 29.85 | 29.85 | - | - | - | - | - |
| 2M | 345.21 ± 12.80 | 10.79 | 21.58 | - | 0.67 | 2.70 | 0.67 | 1.35 |
| 3M | >512 | >16.00 | >8.00 | - | >1.00 | >4.00 | >2.00 | >1.00 |
| 4M | >512 | >32.00 | >16.00 | - | >1.00 | >2.00 | >2.00 | >1.00 |
| 1P | >512 | >128.00 | - | - | - | - | - | - |
| 2P | 55.21 ± 1.69 | 6.90 | 13.80 | 0.43 | 0.86 | 3.45 | 1.73 | 3.45 |
| 3P | 135.46 ± 8.69 | 16.93 | 16.93 | 4.23 | 2.12 | 4.23 | 16.93 | 2.12 |
| 4P | >512 | >128.00 | >64.00 | >16.00 | >8.00 | >16.00 | >64.00 | >8.00 |
| 1S | >512 | - | - | - | - | - | - | - |
| 2S | 21.88 ± 0.68 | 5.47 | 10.94 | 0.34 | 0.68 | 0.17 | 0.68 | 2.74 |
| 3S | 32.11 ± 1.54 | 8.03 | 8.03 | 4.01 | 1.00 | 2.01 | 8.03 | 4.01 |
| 4S | 48.44 ± 4.12 | 12.11 | 6.06 | 6.06 | 3.03 | 6.06 | 12.11 | 3.03 |
| 1Mq | 88.25 ± 1.57 | 2.76 | 2.76 | - | 0.69 | 0.69 | 0.34 | 2.76 |
| 2Mq | >512 | >4.00 | >4.00 | - | - | - | - | >1.00 |
| 3Mq | >512 | >2.00 | - | - | - | - | - | |
| 4Mq | >512 | >4.00 | - | - | - | - | - | |
| 1Pq | 32.21 ± 1.97 | 2.01 | 2.01 | 0.06 | 0.50 | - | 0.13 | 4.03 |
| 2Pq | 133.32 ± 6.27 | 8.33 | 8.33 | 0.26 | 1.04 | 0.26 | 0.26 | 2.08 |
| 3Pq | >512 | >16.00 | >2.00 | - | - | - | - | - |
| 4Pq | >512 | >16.00 | >1.00 | - | - | - | - | - |
| 1Sq | 16.13 ± 9.88 | 4.03 | 2.02 | - | - | - | - | 4.03 |
| 2Sq | 22.42 ± 0.98 | 1.40 | 2.80 | 0.18 | 0.35 | - | 0.35 | 1.40 |
| 3Sq | 385.50 ± 71.51 | 24.09 | 6.02 | 1.51 | 3.01 | 0.75 | 6.02 | 3.01 |
| 4Sq | >512 | >32.00 | >8.00 | 2.00 | >2.00 | >1.00 | >8.00 | >1.00 |
| BAC | 37.98 ± 3.79 | 9.50 | 9.50 | 2.37 | 2.37 | 1.19 | 2.37 | 9.50 |
BAC benzalkonium chloride
*Bolded values refer to compounds with MIC ≤ 32 µg/mL