. 2023 Nov 16;14:1283907. doi: 10.3389/fendo.2023.1283907

Table 2.

Estimated single nucleotide polymorphism (SNP) haplotype frequency with statistics in the region of bilateral 20 SNPs flanking the indel variant rs786204542.

Haplotype Name	Haplotype SNP Composition^a	Affected patients (n=3)		Controls (n=4062)		Fisher’s exact test P-value^b	Permutation P-value^c
Haplotype Name	Haplotype SNP Composition^a	Count	Percent (%)	Count	Percent (%)	Fisher’s exact test P-value^b	Permutation P-value^c
Haplotype A	2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1-2-2-2-2-2-2-1	1	16.67	644	7.93	0.3911
Haplotype B*	2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1-2-2-2-2-2	4	66.67	287	3.53	2.28x10^-5	< 10^-6
Haplotype C	2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1-2-1-2-1-2-1-1-1-2-2-2-2-2-2-2-2-2-2-2-2-1	1	16.67	264	3.25	0.18036
Haplotype D	2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1	0	0	155	1.91
Haplotype E	2-2-2-1-1-2-1-2-2-2-1-1-1-2-2-2-2-1-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1-2-2-2-2	0	0	62	0.76
Haplotype F	2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1-2-2-2-2-2-2-2-2-2-2-2-2-2	0	0	49	0.60
Haplotype G	2-2-2-2-1-2-2-1-2-2-2-2-2-2-1-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1-2-2-2-2-2-2-1	0	0	48	0.59
Haplotype H	2-2-2-2-1-2-2-1-2-2-2-2-2-2-1-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1-2-2	0	0	13	0.16
Haplotype I	2-2-2-2-1-2-2-1-2-2-2-2-2-2-1-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-2-1-2-2-2-2-2	0	0	7	0.09
Haplotype J	2-2-2-1-1-2-1-2-2-2-2-2-2-2-2-2-2-2-1-1-2-2-1-2-2-2-1-2-1-2-2-2-2-2-2-2-2-1-2-2	0	0	2	0.02

^aSNP allele “2”: major allele; SNP allele “1”: minor allele.

^bComparisons of haplotype frequencies between affected patients and controls using Fisher’s exact test.

^cComparison of frequencies of haplotype B between affected patients and controls using permutation test, permutation time=1000000.

*Common haplotype among affected patients.