Fig. 1.

Schematic definition of MAFLD. Adapted from Eslam 2020 [1], with permission. BMI body mass index, HDL-cholesterol high-density lipoprotein-cholesterol, HbA1c glycated haemoglobin, HOMA homeostatic model assessment, hs-CRP high-sensitivity C-reactive protein. *Relates to liver histology from liver biopsy, with ≥ 5% referring to the proportion of hepatocytes containing visible intracellular lipid droplets. Other modalities (imaging, blood biomarkers/scores) have assigned thresholds to detect steatosis at ≥ 5%