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. 2023 Nov 29;7:126. doi: 10.1038/s41698-023-00476-8

Fig. 2. Candidate clinical trial design for latent glioma.

Fig. 2

In patients with latent glioma and CSF access devices, baseline biospecimens and imaging would be acquired prior to initiation of a sequence of senolytics. Biospecimens and imaging would be acquired every 2 weeks to 3 months to assess for pharmacodynamic response based on the CSF SASP. Lack of response would lead to discontinuation of that agent and initiation of the next one in the sequence.