Skip to main content
. 2023 Nov 16;14:1252174. doi: 10.3389/fphar.2023.1252174

FIGURE 4.

FIGURE 4

Effect of therapeutic treatment with minocycline, budesonide, or a combination regimen on colitis severity at the macroscopic and microscopic levels. (A) Percentage of body weight changes in DSS-treated mice receiving vehicle, minocycline (10 mg/kg), and budesonide (0.5 μg/kg), or untreated (UT) mice. Colon length (B), thickness (C), histological assessment of colitis severity (D), and the percentage of ulceration in the whole colon section (E) were determined in mice receiving DSS and either vehicle (solid bars), monotherapy (hatched bars), or a combination regimen (gray bars), and in the UT healthy mice (open bars). Histobars represent means ± SEM for five mice in each group. Asterisks denote a significant difference from UT mice with p < 0.05 (*), # denotes a significant difference from DSS/vehicle-treated mice, and $ denotes a significant difference from monotherapy with p < 0.05. (F) Illustration of colon sections taken from various groups (×10 and ×20 magnifications; bars represent 150 μm).