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. 2023 Nov 16;14:1252174. doi: 10.3389/fphar.2023.1252174

TABLE 2.

Effect of prophylactic treatment with minocycline on the macroscopic scores of colitis severity.

Parameter (%) Edema Erythema Diarrhea Blood in stool Anorectal bleeding Adhesion
UT 0 0 0 0 0 0
Vehicle 100 * 28 * 57 * 0 28 * 100 *
10 mg/kg 85 * 57 * 42 * 0 33 * 42 *#
20 mg/kg 83 * 0 # 0 # 0 0 # 0 #
30 mg/kg 33 *# 0 # 0 # 0 0 # 0 #
40 mg/kg 33 *# 0 # 0 # 0 0 # 0 #

Colitis severity was assessed in UT mice (received tap water only) and mice treated with DSS for 5 days, along with daily i. p administration of minocycline or vehicle (PBS) (n = 7 per group). * denotes a significant difference from UT mice; # denotes a significant difference from DSS/vehicle-treated mice.