TABLE 2.
Parameter (%) | Edema | Erythema | Diarrhea | Blood in stool | Anorectal bleeding | Adhesion |
---|---|---|---|---|---|---|
UT | 0 | 0 | 0 | 0 | 0 | 0 |
Vehicle | 100 * | 28 * | 57 * | 0 | 28 * | 100 * |
10 mg/kg | 85 * | 57 * | 42 * | 0 | 33 * | 42 *# |
20 mg/kg | 83 * | 0 # | 0 # | 0 | 0 # | 0 # |
30 mg/kg | 33 *# | 0 # | 0 # | 0 | 0 # | 0 # |
40 mg/kg | 33 *# | 0 # | 0 # | 0 | 0 # | 0 # |
Colitis severity was assessed in UT mice (received tap water only) and mice treated with DSS for 5 days, along with daily i. p administration of minocycline or vehicle (PBS) (n = 7 per group). * denotes a significant difference from UT mice; # denotes a significant difference from DSS/vehicle-treated mice.